Metformin clinical efficacy

Clinical Efficacy of Metformin HbAlc Lowering, But No Weight Gain... 

Ponzani P, Scardapane M, Nicolucci A, Rossi MC (2016) Effectiveness and safety of Uraglutide after three years of treatment. Minerva Endocrinol 41 35-42 Prasad-Reddy L, Isaacs D (2015) A clinical review of GLP-1 receptor agonists efficacy and safety in diabetes and beyond. Drugs Context 4 212283 Pryor R, Cabreiro F (2015) Repurposing metformin an old drug with new tricks in its binding pockets. Biochem J 471 307-322... 

A systematic review of nine randomised clinical trials of adequate methodological quality addressed the efficacy and safety of metformin combined with lifestyle interventions in the management of adolescent obesity. The results indicate that among obese adolescents with no associated diseases, the administration of metformin is relatively effective in the short term for reducing BMI. Long-term drug s effects were unknown [22 ]. 

Charbonnel B, Steinberg H, Eymard E, Xu L, Thakkar P, Prabhu V, et al. Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with Uraglutide in patients with type 2 diabetes meUitus inadequately controlled on metformin a randomised clinical trial. Diabetologia 2013 56(7) 1503-11. 

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