Metamorphosis and

Thrombin, the two-chain derivative of the prothrombin molecule, has a molecular weight of approximately 37,000 daltons. Its proteolytic properties induce the conversion of fibrinogen to fibrin to produce the initial visible manifestation of coagulation, the soluble fibrin clot. In addition, thrombin influences the activity of Factors V, VIII, and XIII and plasmin. Thrombin affects platelet function by inducing viscous metamorphosis and the release reaction with subsequent aggregation. 

Lefcort, H., R.A. Meguire, L.H. Wilson, and W.F. Ettinger. 1998. Heavy metals alter the survival, growth, metamorphosis, and antipredatory behavior of Columbia spotted frog (Rana luteiventris) tadpoles. Arch. Environ. Contam. Toxicol. 35 447-456. 

Gy Metamorphosis and budding inhibited reduction in pulsation rate 4... 

Prokopchak, M.J., D.P. Spangenberg, and J. Shaeffer. 1990. The effects of X irradiation on the metamorphosis and budding of Aurelia aurita. Radiation Res. 124 34A2. 

Hypothesis 4 An alarm signal exists which reduces time to metamorphosis and mass at metamorphosis of cane toad tadpoles. 

E. J. Physico-Chemical Metamorphosis and Problems in Piezochemistry, McGraw-Hill, New York, 1926. 

Hepatic Effects. No studies were located regarding hepatic effects of 1,2-diphenylhydrazine in Humans. Chronic oral administration of 1,2-diphenylhydrazine produced degenerative alterations the liver of rats (fatty metamorphosis) and mice (coagulative necrosis) (NCI 1978). 

Youson JH, Manzon RG, PeckBJ, Holmes JA (1997) Effects of exogenous thyroxine (T4) and triiodothyronine (T3) on spontaneous metamorphosis and serum T4 and T3 levels in immediately premetamorphic sea lampreys, Petromyzon marinus. J Exp Zool 279 145-155... 

Metamorphosis and budding inhibited reduction in pulsation rate Inhibited reproduction 60% died in 60 days 90% died in 30 days... 

Cohen, R. A. and Pechenik, J. A., Relationship between sediment organic content, metamorphosis, and postlarval performance in the deposit-feeding polychaete Capitella sp. 1, J. Exp. Mar. Biol. Ecol., 240, 1, 1999. 

In summary, natural products have a few known general mechanisms of action. These include toxins, inhibitors of growth, surface-energy modifiers, nervous pathway interference (anesthetics, including nitric oxide synthase inhibitors and neurotransmitter blockers), inhibitors of attachment, inhibitors of metamorphosis, and repellants.46 55117118 It is likely that many compounds have multiple mechanisms of action. 

Physico-Chemical Metamorphosis and some Problems in Piezo-Chemistry, by... 

To date, interest in the ecdysteroids has focused primarily on their role in insect molting and metamorphosis and it is perhaps somewhat unfortunate that bioassays for ecdysteroid activity have been restricted almost exclusively to evaluating their effect on the molting process. It now appears probable that molting is just one of several important regulatory functions (e.g., embryogenesis, reproduction) performed by the ecdysteroids and that we are only just beginning to scratch the surface of an insect steroid system that is equally as complex as that in vertebrate species. 

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