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Metalloprotease-disintegrins

Yagami-Hiromasa T, Sato T, Kurisaki T, et al A metalloprotease-disintegrin participating in myoblast fusion. Nature 1995 377 652-656. (NC)... [Pg.29]

ROLES OF METALLOPROTEASE-DISINTEGRINS IN CELL-CELL INTERACTIONS, IN NEUROGENESIS, AND IN THE CLEAVAGE OF TNFa... [Pg.165]

B. Identification of the TNFa Convertase Suggests that Metalloprotease-Disintegrins Play a Role in Protein... [Pg.166]

XII. Metalloprotease-Disintegrin Expression Patterns during Development.189... [Pg.166]

The purpose of this review is to discuss what is currently known about the different functions of metalloprotease-disintegrins, and to highlight some of the most interesting and pressing questions that have now been raised about this intriguing protein family. A brief summary of the known properties of snake venom disin-tegrins and metalloproteases is followed by a discussion of the role of membrane-anchored metalloprotease-disintegrins in cell-cell interactions and proteolysis of extracytoplasmic or extracellular protein domains. [Pg.167]

To corroborate the peptide inhibition studies, it will now be essential to analyze the function of expressed metalloprotease-disintegrin protein domains or of intact proteins and to evaluate their ability to bind to specific integrins. Employing expressed protein domains or purified proteins may also reveal if other parts of a metalloprotease-... [Pg.172]

VI. EVIDENCE FOR A POTENTIAL ROLE OF METALLOPROTEASE-DISINTEGRINS AS INTEGRIN LIGANDS IN SOMATIC CELL-CELL INTERACTIONS... [Pg.175]

The first evidence for metalloprotease activity of a membrane-anchored metalloprotease-disintegrin was provided by P. Glynn and colleagues, who purified... [Pg.179]

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Disintegrin

Metalloproteases

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