Metal coordination based recognition

Template-metal coordinative bonds have also been used in the imprinting and recognition of carbohydrates in aqueous media. A MIP, templated with glucose and using 4-(iV-vinylbenzyl)diethylenetriamine)Cu(H)]diformate as 

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The previous section described the supramolecular side chain functionalization of polymers based on a single recognition motif. However, biological systems use a wide variety of noncovalent interactions such as hydrogen bonding, metal coordination, and hydrophobic interactions in an orthogonal fashion to introduce function,... 

Figure 5.8 Three recognition motifs based on (a) hydrogen bonding interactions between 2,6-diaminopyridine and thymine, (b) metal coordination of suUur-carbon-sulfur (SCS) Pd pincer with pyridine, (c) pseudorotaxane formation between dibenzo[24]crovvn-8 (DB24C8) and dibenzylammonium ions, and (d) fuUy functionaUzed terpolymer 5.

Arnold and co-workers have developed an approach that allows both the imprinting and the subsequent chiral separation of free amino acids to be carried out in aqueous solutions [39]. The recognition was based on metal coordination-chelation interactions using A-(4-vinylbenzyl)iminodiacetic acid as the functional monomer. (For a further discussion of this system see Chapters 6 and 9.) The method worked best for aromatic amino acids (Fig. 17.11). 

Fugii et al. [26] reported one of the earliest examples of selective recognition using metal coordinated molecular imprinting. They utilized a polymerizable cobalt (III) Schiff base complex as the recognition element in an MIP designed for the selective... 

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