Metal containing drug

Cisplatin, (ds-[PtCl2(NH3)2], also known as cis-DDP) ((1), Figure 2) is perhaps the best known example of a small molecule metal-containing drug. The clinically used platinum complexes are shown in Figure 2. The history of the discovery and development of cisplatin remains a remarkable scientific story.33 Its use and effectiveness in cancer chemotherapy since the entry into the clinic in the late 1970s has been thoroughly documented.34-36 Cisplatin is cited for treatment of... 

Because of the use of various electrolyte systems, pH gradients, and not least an electric field, some complexes would not survive the separation. It is therefore necessary that the species to be separated are both thermodynamically and kineti-cally stable. Recently, Bocek and Foret have reviewed the application of isotachophoresis to the separation of inorganic species. This technique appears to be well-suited for the study of the distribution of metabolites of metal-containing drugs in body fluids. A survey of the application of electrophoretic techniques to biological materials can be found in the book edited by Deyl... 

Design and study of metal-containing drugs to cure or prevent diseases (synthesis, mechanism of action)... 

Figure 2 Structures of some important metal-containing drugs (R = organic fragment).

Modulation of Cellular Responses by Metal-containing Drugs... 

Metal ions not only play a role in structure, transport or catalysis, but they may also have deleterious effects as a toxic metal (see above), or play an important role as a metal-containing drug or diagnostic agent. Examples of the last category are ... 

Table 1 General Biological Uses for Metal-Containing Drugs...

Studies of the roles of metal ions in AD fall within the field of metals in medidne. In addition to analysis of how metal ions naturally present within an organism play a role in health and disease, this field also indudes the study of the effeds of metals introduced to the body, whether unintentionally (such as mercury in your tuna sushi) or intentionally in the form of metal-containing drugs. I thought I d write a bit about metallopharmaceuticals, an area with a long history and continued promise. 

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