Metal-catalyzed C—H functionalization

Synthesis of pyrroles, indoles, and carbazoles through transition-metal-catalyzed C—H functionalization 13AJ0466. 

A Journey Through Metal-Catalyzed C—H Functionalization of Heterocycles Insights and Trends... 

Based on the rapid development of C-H activation in the past few decades, palladium-catalyzed synthesis of oxygen-containing heterocycles via C-H activation has been obtained a significant progress in turn, these achievements also promoted the advance of transition metal-catalyzed C-H functionalization. A broad scope of oxacycles has been synthesized via this approach. Some of these structures are even difficult to access through the conventional methods and hence highlight the palladium-catalyzed C-H activation a powerful and efficient method to achieve novel transformations. 

Over the past few years, transition metal-catalyzed C-H functionalization methods for the formation of the C-C bonds have been well explored, many of which have included a handful of impressive strategies and synthetically valuable heterocycles when the starting materials contain heteroatoms. Among them, iron salts showed particular fascination for such purposes. In 2010, Liang and coworkers reported a new iron-catalyzed dual C-H activation between aryl C(sp )-H and vinyl C(sp )-H bond activation to build substituted indoles in the presence of Cu(OAc)2-CuCl2 (Scheme 9.13) [16]. This reaction showed highly functional group tolerance and exhibited different properties from the palladium-catalyzed reactions of this type. 

The book summarizes all aspects of metal-catalyzed C-H functionalizations of relevance to the synthesis and diversification of heterocycles, which should prove invaluable for scientists working in academia as well as practitioners in an industrial environment. Thus, this book is expected to be found in libraries and on the bookshelves of chemists who enjoy chemical synthesis, catalysis, and medicinal chemistry. 

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