Metal-binding motif

Wulfing, C., Lombardero, J. and Pluckthun, A. (1994) An Escherichia coli protein consisting of a domain homologous to FK506-binding proteins (FKBP) and a new metal binding motif. Journal of Biological Chemistry 269, 2895-2901. 

Figure 5 Symmetry of the planar two-metal binding motif.

The A, AT, 0-binding motif is found in many non-heme iron enzymes as well as in some zinc enzymes as metal-binding motif Thus, to mimic this motif is the purpose of small organic 0-ligands such as... 

The hype proteins are all relatively small proteins of between 75 and 108 amino acid residues which do not contain obvious metal-binding motifs. As will be discussed below (Section 4.5), these proteins may act as chaperones for hydrogenases during the process of matnration. This has been suggested from the studies of the interaction... 

Figure 1 Metal-binding motifs and domains, (a) Ni Xaa-Xaa-His motif. (Reprinted with permission from Ref. 30. 1999 the American Chemical Society) (b) His-X3-His motif. (Reprinted with permission from Ref. 23. 2001 the American Chemical Society) (c) Cys-Xaa-Xaa-Cys motif. (Reprinted with permission from B.R. Gibney, S.E. Mntholland, F. Rahanal, and P.L. Dntton, Proc. Natl. Acad. Sci. U.S.A., 1996,93, 15041. 1996 National Academy of Sciences, USA) (d) Zinc finger domain. (Reprinted with permission from Ref. 28. 2004 the American Chemical Society)...

Similar metal-binding motifs are common in varions proteins and peptides with metal-binding capabiUties. Snznki etal. examined the metal-binding characteristics of one such protein, the heavy metal-binding protein Cdll9 from Arabidopsis The anthors prepared the 225 amino acid... 

An interesting metal-binding motif in proteins is the zinc finger, which contains a / ribbon-turn-a helix motif that binds a zinc ion via four sulfur atoms of cysteine residues, or via two such sulfur atoms and two nitrogen atoms (from histidine). This motif, first identified by NMR studies, has been found in the crystal structures of several protein-nucleic acid complexes. ... 

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