Metabolite kuanoniamine

Thiazolopyridoacridine alkaloids obtained from marine sources, kuanoniamines (2a-c), bright yellow metabolites from the mollusk Chelynotus semperi, display... 

Kuanoniamines A-D (213-216) were isolated from an unidentified Mi-cronesian purple colonial tunicate and its predator, Chelynotus semperi, and exhibits cytotoxicity (177). Judging from the more than 20 examples mentioned above, it seems likely that these metabolites embracing the common tetracyclic unit (189) should be classed together biosynthetically. The diversity of source organisms would suggest that the metabolites are produced by symbionts. 

An examination of the composition of polyaromatic alkaloids of the mollusk Chelynotus semperi and an unidentified tunicate, both collected from Mante channel, Pohnpei, resulted in the identification of shermilamine B [129] and kuanoniamines A-D [130-133] (105). Shermilamine was originally found as a metabolite of a tunicate of the genus TruUdanmon (106). 

EtOAc (6 4) as eluant to yield pure kuanoniamine A. These metabolites were also isolated from a mollusk Chelynotus semperi, which was observed to eat the ascidian. 

Thiazolopyridoacridine alkaloids obtained from marine sources, kuanoniamines (2a-c), bright yellow metabolites from the mollusk Chelynotus semperi, display only modest cytotoxicity. They strongly coordinate divalent ions (Fe, Co , Cu, Xeq 10 ° M ) and are pH indicators, their color changing from... 

---