Metabolic fate of hydroperoxides and secondary products

Whether and to what extent oxidized oils are absorbed and incorporated into the tissues of experimental subjects have been investigated. The absorption of oxidized oils has been reported, but with conflicting results 

The findings suggest that most of the injected hydroperoxides were metabolized or decomposed. 

Due to the function of GSH peroxidase in metabolizing lipid hydroperoxides, the nutritional status of selenium may determine cellular susceptibility to the effects of peroxidized Upid administered. By feeding 7% oxidized stripped corn oil (peroxide value lOOOmequiv./kg) in a diet adequate in selenium and vitamin E to weanling rats for 14 weeks, Vilas et al. (1976) have shown an increase in specific activity of GSH peroxidase 

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