Mesonephric remnants

Mesonephric duct remnants may be found in the deep wall of cervix specimens. Sometimes, hyperplasia may be pronounced and raise concern for minimal deviation type endocervical adenocarcinoma. Apical expression of CD 10 is common in these remnants, as is expression by the intraluminal secretions. CD 10, however, is not pathognomonic for mesonephric differentiation because some endocervical and endometrial adenocarcinomas may express CDIO. Minimal deviation type endocervical adenocarcinoma, however, lacks CDIO expression. Variable expression of pi6 is reported in mesonephric remnants and may lead to misinterpretation as endocervical adenocarcinoma however, MIBl is not increased. ER, PR, and CEA are generally negative. The immuno-phenotype is similar in mesonephric adenocarcinoma as well. " ... 

FIGURE 18.11 Minimal deviation endocervical adenocarcinoma consists of a deeply invasive, haphazardly infiltrative proliferation of bland endocervical glands that, in a small tissue sampling, may mimic endocervical glandular hyperplasia or mesonephric remnants (A). (H E.) Some cases may express CEA (B), which is not expressed by its benign mimics. 

Tiltman AJ, Allard U. Female adnexal tumours of probable Wolffian origin An immunohistochemical study comparing tumours, mesonephric remnants and paramesonephric derivatives. Histopathology. 2001 38 237-242. 

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