Mesonephric duct

Efferent ducts (derived — from mesonephric ducts) + + + + ( )... 

Mesonephric duct remnants may be found in the deep wall of cervix specimens. Sometimes, hyperplasia may be pronounced and raise concern for minimal deviation type endocervical adenocarcinoma. Apical expression of CD 10 is common in these remnants, as is expression by the intraluminal secretions. CD 10, however, is not pathognomonic for mesonephric differentiation because some endocervical and endometrial adenocarcinomas may express CDIO. Minimal deviation type endocervical adenocarcinoma, however, lacks CDIO expression. Variable expression of pi6 is reported in mesonephric remnants and may lead to misinterpretation as endocervical adenocarcinoma however, MIBl is not increased. ER, PR, and CEA are generally negative. The immuno-phenotype is similar in mesonephric adenocarcinoma as well. " ... 

Near the end of the 3rd week after conception, the pronephros begins to form. The proximal ends form nephrostomes, which open into the coelomic cavity, and the distal ends of successive tubules coalesce to form the pronephric ducts. The cephalic segments regress before the caudal parts form and all degenerate by the 5th week. The pronephros appears to be nonfunctional in humans, but is important in giving rise to the mesonephric ducts. 

The bladder develops mainly from the vesical part of the urogenital sinus. The trigone region is derived from the caudal end of the mesonephric ducts. 

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