Mesantoin - Mephenytoin

Hydantoins Ethotoin (Peganone) Fosphenytoin (Cerebyx) Mephenytoin (Mesantoin) Phenytoin (Dilantin) Primary effect is to stabilize membrane by blocking sodium channels in repetitive-firing neurons higher concentrations may also influence concentrations of other neurotransmitters (GABA, norepinephrine, others)... 

This category includes phenytoin (Dilantin), mephenytoin (Mesantoin), ethotoin (Peganone), and fosphenytoin (Cerebyx). Phenytoin is often the first... 

Mephenytoin has been extensively used for phenotyping purposes however, such use is not without practical problems. For example, sedation is often observed in PMs, especially those of small body size, e.g., children and Southeast Asians, following administration of a 100-mg dose usually used for phenotyping (178). Accordingly, a dose of 50-mg mephenytoin is often used to phenotype such individuals. A further complicating factor is that racemic mephenytoin (Mesantoin , Sandoz/Novartis, Basal, Switzerland) is not available in many parts of the world. For these reasons, other in vivo probes have been investigated. 

Snead, C., Siegel, N. and Hayslett,). (1976) Generalised lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity. Pediatrics, 57, 98. 

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