Mercury compounds indoles

All of the attempted generations of this type of aryne to date have involved organometalic precursors or strongly basic reaction conditions, either of which is incompatible with the presence of the N-H group of the indole nucleus. Consequently only the preparation of the iV-methyl derivative 31 has been investigated. Decomposition of the mercury compound 231 in the presence of tetracyclone (151) gave both the expected aryne adduct (232) and 3-chloro-A -methylindole (233). The isolation of the latter compound indicates that the precursor 231 decomposes by a stepwise process probably via the radical 234. Reaction of tetracyclone (151) with either this radical or directly with the... 

Electrochemical detectors are based upon the volta-metric oxidation or reduction of separated analytes at a micro- or thin-film electrode. A number of pharmacologically active compounds that are aldehydes, ketones, or quinones (such as doxorubicin), or nitro compounds (such as nitrofurantoin) are amenable to reduction at a mercury or platinum electrode electron-rich indole derivatives and catecholamines can be oxidized at these electrodes. An important condition that must be fulfilled for electrochemical detection to be practicable is that the mobile phase must be capable of conducting an electrical current. This makes electrochemical detection particularly useful in reversed-phase liquid chromatography, where buffered water mixed with one or more organic cosolvents is usually the mobile phase. 

Dimethylsulfoxide Photoaddition of the compound to the indole nucleus occurs, when poly-tryptophan is subjected to photolysis with a high pressure mercury lamp HI)... 

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