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Mercury chemical toxicology

Clarkson, T. W., Mercury Poisoning Clinical Chemistry and Chemical Toxicology of Metals, 189-204, Elsevier, Amsterdam (1977)... [Pg.376]

Clarkson TW, Magos L The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 2006 36 609. [PMID 16973445]... [Pg.1245]

HBM values are derived from toxicologic and human studies and are health based (Jakubowski and Trzcinka-Ochocka 2005). Two types of HBM values exist HBM I, the concentration of an environmental toxin in human biological material below which there is no risk of adverse health effects and HBM II, the concentration above which there is an increased risk of adverse health effects in susceptible individuals in the general population (Jakubowski and Trzcinka-Ochocka 2005). An HBM I value serves as an alert level, and an HBM II value is an action level at which immediate efforts should be made to reduce exposure and further clinical examination should follow (Ewers et al. 1999). HBM values and reference values have been derived for a number of chemicals, including lead, cadmium, mercury, pentachlorophenol (PCP), and arsenic. [Pg.85]

The approaches described previously can be used to relate biomonitoring results to a reference population or to workplace exposures, but they do not evaluate the risk associated with the amount of a chemical found in the body. To do that, one needs to develop a relationship between biomarker concentration and toxic response, a relationship that is not commonly derived in standard toxicologic practice. The following sections outline methods for deriving such a relationship. The approaches include the ideal case of existing risk assessments based on biomarker-response relationships established in epidemiologic research. Lead and mercury are used as examples of cases in which exposure was quantified according to hair or blood biomarkers and dose-response associations were developed on this basis. [Pg.183]

Clarkson T, Magos L. The Toxicology of Mercury and Its Chemical Compounds. Critical Reviews in Toxicology 2006, 36, 609-662. [Pg.105]


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Toxicology mercury

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