2-mercapto-4 -quinazolinone

The reaction of the anhydride 1 with amines in dioxane (20°C, 2 h) [112], alcohol (boiling, 2 h) [113], or benzene (boiling, 10 h) [114] gave 63-83% yields of anthranilic acid derivatives 189, which were converted by the action of hydrogen sulfide in the presence of potassium hydroxide into 2-mercapto-4-quinazolinones 190 (yields 40-92%) [112-114],... [Pg.30]

Substituted 2-mercapto-4(3i/)quinazolinones were prepared by condensing methyl anthranilate with isothiocyanates (see 7c). [Pg.298]

Treatment of 2-mercapto-4(3W)-quinazolinone (52) with hydrazonoyl halides affords 1,3-disubstituted l,2,4-triazolo[4,3-a]quinazolin-5-ones 53 [95H(41)1999]. Hydrazones derived from [(2-methyl-4-quinazolinyl)oxy]acetic acid hydrazide and aldehydes or ketones were shown to give 4-thiazolidinones and pyrazoles under cyclization conditions [95UC(B)537]. [Pg.242]

Thiazolo[2,3-h]quinazolines [C S-C JV2-CeJ. The cycloaddition reaction of alkah-metal salts of 2-mercapto-4(3/f)-quinazolinones with 3-benzoyl-3-bromopropionic acids and esters gives acids (250) and lactones (251). ... [Pg.188]

Quinazolinones bearing an acetic acid ester moiety at A -3 or a mercapto-acetic acid ester substructure in position 2 have been evaluated as H -anti-histaminics (93AF(43)663J. Cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells have been reported for (E)-5-(2-acylvinyl)uracils (93MI(28)473). [Pg.237]

The reaction of the anhydride 1 with 3-amino-2-mercaptoquinazolin-4(3H)-one (191) gave a 76% yield of the anthranilic acid derivative 192, which was converted by the action of hydrogen sulfide in alcohol into 3,3-bis(2-mercapto-4(3H)-quinazolinone) (193) with a yield of 85% [115],... [Pg.31]

Quinoxalino[2 3 -4,5]thiazolo[3,2-a(and 6)]quinazolines.—[C3NS-C4N2-C4-N2-C6-Ce]. The condensation of 2,3-dichloroquinoxaline (355) and 2-mercapto-4-(3 )quinazolinone (356) yields a mixture, separable by preparative thin-layer chromatography, of 5 -quinoxalino[2, 3 -4,5]-thiazolo[3,2-fl]quinazolin-5-one (357) and its [3,2-6] isomer (358). The... [Pg.716]

Cai X, Kalcher K, Lintschinger J, Neuhold C (1993) Stripping voltammetric determination of trace amounts of mercury using a carbon paste electrode modified with 2-mercapto-4(3H)-quinazolinone. Mikrochim Acta 112 135-146... [Pg.488]

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