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Mephobarbital

Figure 11.19 SPME-CE analysis of urine samples (a) blank urine (a) directly injected and extracted for (b) 5 (c) 10 and (d) 30 min (b) Urine spiked with barbiturates, extracted for (e) 30 and (f, g) 5 min. Peak identification is as follows 1, pentobaitibal 2, butabarbital 3, secobarbital 4, amobarbital 5, aprobarbital 6, mephobarbital 7, butalbital 8, thiopental. Concenti ations used are 0.15-1.0 ppm (e, f) and 0.05-0.3 ppm (g). Reprinted from Analytical Chemistry, 69, S. Li and S. G. Weber, Determination of barbiturates by solid-phase microexti action and capillary electrophoresis, pp. 1217-1222, copyright 1997, with permission from the American Chemical Society. Figure 11.19 SPME-CE analysis of urine samples (a) blank urine (a) directly injected and extracted for (b) 5 (c) 10 and (d) 30 min (b) Urine spiked with barbiturates, extracted for (e) 30 and (f, g) 5 min. Peak identification is as follows 1, pentobaitibal 2, butabarbital 3, secobarbital 4, amobarbital 5, aprobarbital 6, mephobarbital 7, butalbital 8, thiopental. Concenti ations used are 0.15-1.0 ppm (e, f) and 0.05-0.3 ppm (g). Reprinted from Analytical Chemistry, 69, S. Li and S. G. Weber, Determination of barbiturates by solid-phase microexti action and capillary electrophoresis, pp. 1217-1222, copyright 1997, with permission from the American Chemical Society.
The selectivity of another cellulose-based CSP, Chiralcel OJ, has also been examined in SFC [60]. Separations of racemic drugs such as benoxaprofen, temazepam, and mephobarbital were obtained. Acetonitrile proved to be a better modifier than methanol for some of the compounds investigated. The four optical isomers of a calcium channel blocker were resolved by Siret et al. on the Chiralcel OJ CSP [30]. In LC, two CSPs were required to perform the same separation. [Pg.309]

Long-acting (eg, phenobarbital, mephobarbital [Mebaral]). The averse duration of action of the long-acting barbiturates is 10 to 16 hours. [Pg.237]

Long-acting barbiturates used as sedative-hypnotics and also for their anticonvulsant effects include phenobarbital (Luminal) and mephobarbital (Mebaral). [Pg.139]

Methylphenobarbitone (mephobarbital, 284) was stable to light in neutral solution but in alkaline buffer, where the anion was present, it gave carbon monoxide and a 40% yield of the imidazole (293) [174]. [Pg.98]

In certain specific cases either the pure pharmaceutical substance or dosage forms are quantitatively converted to free compound. This conversion to free compound is quantitative and hence forms the basis of gravimetric analysis. A few typical examples belonging to this category are, namely progesterone suspension sterile, progesterone tablets, sodium lauryl sulphate, mephobarbital tablets and sorbitan monooleate. [Pg.183]

Procedure Weigh and finely powder not less than 20 mephobarbital tablets. Transfer an accurately weighed portion of the powder equivalent to about 300 mg of mephobarbital to an extraction thimble. Extract with 15 ml of solvent hexane, allow the thimble to drain, transfer to a continuous extraction apparatus provided with a tared flask, and extract the mephobarbital with chloroform for 2 hours. Evaporate the chloroform on a steam bath with the aid of a current of air, cool, dissolve the residue in about 10 ml of alcohol, evaporate, dry the residue at 105°C for 1 hour, cool and weigh. [Pg.183]

Meperidine, 299, 300, 303, 306 reversed, 303 Mephenesin, 118 Mephenesin carbamate, 118 Mephenhydramine, 44 Mephenoxolone, 119 Mephentermine, 72 Mephenytoin, 246 Mephobarbital, 273 Mepivacaine, 17 Meprobamate, 218 Mequoqualone, 354 Meralluride, 224 Mercaptomerine, 224 Mesoridazine, 389 Mesterolone, 174... [Pg.483]

Mephobarbital Mephobarbital, 5-ethyl-l-methyl-5-phenylbarbituric acid (4.1.8), is synthesized according to one of the diagrams used for the phenobarbital synthesis, except one uses methylurea instead [5]. [Pg.60]

Mephobarbital is used as a sedative agent for relieving anxiety and tension as well as for major and minor epileptic attacks. Synonyms for this drug are barbefenal, enfenemal, and methylphenobarbital. [Pg.60]

From the chemical point of view, formally, antiepileptic drugs could be classified as derivatives of hydantoins (phenytoin, mephenytoin, ethotoin), barbiturates (phenobarbital, mephobarbital, and primidone), succinimides (ethosuximide, methosuximide, phensux-imide), benzodiazepines (diazepam, chlorodiazepoxide, clonazepam, lorazepam), oxazo-lidines (trimethadione, paramethadione), and also valproic acid, carbamazepine, and acetazolamide. [Pg.125]

Other drugs described above, such as mephobarbital (4.1.8) and metharbital (4.1.9) are also used in treating epilepsy. [Pg.127]

Anticonvulsant (mephobarbital, phenobarbital) Treatment of partial and generalized tonic-clonic and cortical focal seizures. [Pg.1196]

Pharmacology These agents depress the sensory cortex, decrease motor activity, alter cerebellar function, and produce drowsiness, sedation, and hypnosis. Barbiturates have little analgesic action at subanesthetic doses and may increase the reaction to painful stimuli. All barbiturates exhibit anticonvulsant activity in anesthetic doses. However, only phenobarbital and mephobarbital are effective as oral anticonvulsants in subhypnotic doses. [Pg.1200]

Use mephobarbital with caution in myasthenia gravis and myxedema. [Pg.1202]

Two other barbiturates, mephobarbital Mebaral) and metharbital Gemonit) continue to be marketed as anticonvulsant drugs, but they are infrequently used. [Pg.381]

Contraindications Porphyria, history of hypersensitivity to mephobarbital or other... [Pg.749]


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Mephobarbital tablets

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