Membrane-water partition coefficient thermodynamics

In terms of the characterization of the thermodynamic behavior, the phase diagram and the variation of response functions - for example specific heat and the membrane-water partition coefficients seen in crossing the phase diagram - are important indicators of the molecular interactions [49],... 

Based on thermodynamic arguments, it has been suggested that octanol does not accurately represents fish lipids [81]. Lipid solubility has been proposed as an additional parameter based on the argument that lipids are more structured than octanol [82]. Partition coefficients with other solvents (triolein-water) and membrane vesicles are measured and related to as well as to BCF [32, 83, 84]. In general, these latter partition coefficients fairly correlate with Kq with systematic lower values at high These differences may lead to an apparently lower BCR The consequences are that overestimates bioaccumulation for very hydrophobic compounds. 

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