Melatonin chemical nature

Antioxidants of a different chemical nature have been investigated for use as therapeutic agents, either alone or in combination. Combination of a known antioxidant compound with indole ring or melatonin analogue compounds is a new trend in antioxidant chemistry. 

Serotonin and melatonin are evidently involved in maintenance of the 24-h circadian rhythm of the body (see Section 13).792/792a Melatonin regulates the sexual cycle in photoperiodic animals and influences the onset of puberty.792-794 The serotonin content of the brain is influenced by the diet, being higher after a meal rich in carbohydrates. Serotonin may serve as a chemical message sent from one set of neurons to the rest of the brain, reporting on the nature of dietary intake.784 Melatonin, which can readily form free radicals, may function as part of the body s antioxidant system.795 796... 

The medical use of botanicals in their natural and unprocessed form undoubtedly began when the first intelligent animals noticed that certain food plants altered particular body functions. Much information exists about the historical use and effectiveness of botanical products. Unfortunately, the quality of this information is extremely variable. One of the most complete compendiums of clinical recommendations regarding the use of botanicals is the Report of the German Commission E (a committee that sets standards for herbal medications in that country Blumenthal, 2000). Interest in the endocrine effects and possible nutritional benefits of certain purified chemicals such as dehydroepiandrosterone. melatonin, high-dose vitamins, and minerals has led to a parallel development of consumer demand for such substances. These substances, together with the botanicals, constitute a substantial source of profits for those who exploit the concept of "alternative medicine."... 

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