Medicines Simvastatin

For sale as a P medicine, simvastatin 10 mg at a dose of one 10 mg tablet each night, on a long-term basis is indicated to reduce the risk of a first major coronary event in individuals at moderate risk of CF1D, including ... 

Erythromycin may cause increases in the semm levels of simvastatin. The CSM has advised that this should not be co-prescribed with simvastatin. In the first instance the pharmacist should check local policies for management of hospital acquired chest infections/pneumonia to ascertain first and second line choices. If erythromycin or any macrolide cannot be avoided then a practical way forward may be to avoid taking any dose of simvastatin for the duration of the course of macrolide. In addition a recent Dmg Safety Update from the Medicines and Healthcare Products Regulatory Agency (MHRA, 2008) on statins has highlighted statin dmg interactions and the appropriate actions to take. 

The UK Medicines and Healthcare Products Regulatory Agency (MHRA) data show that several deaths have occurred from hepatotoxicity. Most reports of hepatic adverse drug reactions (ADRs) relate to atorvastatin and simvastatin [36]. There are relatively fewer for pravastatin and fluvastatin. However, this may reflect their ... 

The book deals with the minor illnesses or conditions that can be self-treated with advice and treatment from a pharmacist. Three chapters deal with medicines (Chapter 24, nicotine replacement therapy Chapter 32, emergency hormonal contraception and Chapter 2, simvastatin) that have become available without prescription within the last few years and are not treatments for illnesses but are used prophylactically or preventively. 

In addition to the licensing conditions, the RPSGB recommends the following good-practice measures in association with the over-the-counter sale of simvastatin Pharmacists should be involved in all initial sales but subsequent sales may be delegated to appropriately trained medicines counter assistants. 

Y. Kureishi, Z. Luo, 1. Shiojima, et al The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic. animals. Nature Medicine 6, 1004 (2000). 

HMG-CoA reductase is the rate-determining enzyme of sterol synthesis, and its activity is regulated by competitive inhibition by compounds that bind to the same site as HMG-CoA. It is also regulated by substances that bind to other (allosteric) sites on the enzyme molecule. Inhibitors of this enzyme (e.g., simvastatin) are used as medicines to reduce cholesterol in patients whose cholesterol levels are too high. Through feedback inhibition, cholesterol is a strong inhibitor of the enzyme itself. No fungicides with this mode of action have yet been developed, but the possibility that they will be exists. 

Simian immunodeficiency vims (SIV) 556 Similar Biological Medicinal Products Legislation (SBMPL) 1764 Simulect 21, 456, 1086 Simvastatin 58... 

The compounds shown here are widely used in medicine. Ampicillin is an antibiotic, and simvastatin is a cholesterol-lowering drug. Locate the chirality centers in each. 

Controlling cholesterol levels in the body is an important part of healthy living. Recent advances in medicinal and organic chemistry have allowed the development of the statin drugs (i.e., atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, and rosuvastatin), which act to reduce the level of unhealthy low-density lipoprotein (LDL) cholesterol. Examples of a healthy artery and a partially clogged... 

---