Medicinal interest fused heterocycles

The recent discovery of different types of biological activity in spiro-fused heterocyclic compounds has generated considerable interest among synthetic and medicinal organic chemists [124], The synthesis and chemistry of spiro-fused P-lactams have also developed steadily. Most of the methods apphcable to the synthesis of monocychc fS-lactams are apphcable with certain hmitations to the synthesis of spiro-fused 2-azetidinones [125]. The literature survey reveals the synthesis of several natural products inspired spiro-2-azetidinones having antimicrobial activity, cholesterol absorption inhibition activity, antiviral activity, and fS-lactamase inhibition activity [126]. 

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