Meclozine

Other pharmaceutical chemicals such as calcium gluconate, ferrous salts, nikethamide, glycerophosphates, chloral hydrate, saccharin, antihistamines (including meclozine, and buclozine), tranquilizers (including meprobamate and chloropromazine), antifilarials, diethylcarbamazine citrate, and oral antidiabetics, including tolbutamide and chloropropamide ... 

Common Name Meclozin histamethizine Structural Formula ... 

Reference compounds. Meclozine Rf 79, caffeine Rf 58, dipipanone Rf 33, desipramine Rf 11. 

Antiemetics such as meclozine and prochlorperazine may alleviate light-headedness. In benign postural light-headedness the best treatment is mobilisation and some physical manoeuvres. Do not forget... 

As first choice treatment a well-established antihistamine such as meclozine is recommended. Promethazine is another antihistamine which reduces nausea, but sedation is a not always desired adverse effect. Metoclopramide increases intestinal motility and could be used short term also early in pregnancy. A neuroleptic such as prochlorperazine reduces nausea but should only be used for shortterm treatment due to the risk of extrapyramidal adverse reactions. Serotonin receptor antagonists can be used in post-operahve nausea and during treatment with cytostatics. 

Cyclizine has antimuscarinic properties and is a potent anti-emetic, effective for the control of postoperative and drug-induced nausea and vomiting. It has been used to prevent motion sickness, although diphenhydramine and promethazine are more effective. It is available in oral and parenteral formulations. In contrast to many other first-generation antihistamines sedation is not marked. It is available in tablet form as the hydrochloride and in injectable form as the lactate. Because of its anticholinergic action, blurred vision and dry mouth are associated with clinical doses. When given by rapid intravenous injection tachycardia may be a problem. Meclozine is a related drug which, like cyclizine, is used primarily for motion sickness. 

Saket, M. 1996. Comparative evaluation of micellar solubilization and cyclodextrin inclusion complexation for meclozine hydrochlorideMexandria J. Pharm. Scfl0 13—18. 

Saket, M. 1997. Improvement of solubility and dissolution rate of meclozine hydrochloride utilizing cyclodex-trins and non-ionic surfactant solutions containing cosolvents and additietesTechnol. Legis Med. 8 33-48. 

Beadox Benadon Hexa-Betalin (7) Hexavibox, Hexabion Pyrivel Pyridipca Becilan, Hexermin Campoviton 6 (1) Comploment Ancoloxin (with meclozine hydrochloride) (3). 

Auditory hallucinations have been reported in a 42-year-old man taking a combination of meclozine 25 mg bd and metaxalone 800 mg bd (75). The hallucinations ceased when the medications were withdrawn. 

Loss of memory, confusion, and disorientation has been ascribed to meclozine in an 85-year-old woman (SEDA-13, 132). 

Reference Compounds. Meclozine Rf 70, mepiv-acaine Rf48, procaine Rf30, amitriptyline Rf 15. 

Infra-red Spectrum. Principal peaks at wavenumbers 700, 720, 760, 940, 805,1491 (meclozine hydrochloride, KBrdisk). 

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