Measuring change in blood pressure over time

Idble 4.1 Examples of endpoints used in clinical trials of experimental drugs [Pg.43]

Uncomplicated urinary tract infection Eradication of bacterial pathogen [Pg.43]

6 Uniformity of blood pressure 4.7 Measuring change in blood [Pg.43]

As antihypertensive drugs are intended to lower blood pressure, their evaluation in clinical trials requires at least two measurements. One of these is an initial measurement, typically called a baseline measurement, and the other is a measurement some time later, such as at the end of the treatment phase (the end-of-treatment measurement). These two measurements allow us to calculate a change score that represents the change in blood pressure from the start to the end of the treatment phase. Change scores can be calculated in several ways. One of these, and the method that is used in all of the examples in this book, is simply to calculate the arithmetic difference between each individual s baseline measurement and his or her end-of-treatment measurement. [Pg.43]

It is also possible that blood pressure may be measured more than twice in a trial. If the treatment period is 12 weeks long, measurements [Pg.43]

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