Maytenus serrata

Maytenus serrata (Hochst. ex A. Rich) Wilcz. M. hookeri Loes. Mei Deng Mu (fruit, bark, rhizome) Maytansine, maytanprine, maytanbutine, maytanvahne, maytanacine, maytansinol.33 Treat lung cancer, breast and ovarian cancer, acute lymphocytic leukemia, colon carcinoma, kidney carcinoma. 

Oxazinomycin (l)5 is a 1,3-oxazine antibiotic. There are five other antileukemic antibiotic macrolides of known tetrahydro-l,3-oxazine-2-one structures. Maytansine, Maytanprine, and Maytanbutine were found by Kupchan et a/.278,278 in Maytenus ovatus and Maytenus buchananii, and in Maytenus serrata by Meyers et al.,277 and Calubrinol... 

Maytansines Maytenus serrata i Maytenus buchananii > (Celastraceae) Putterlickia verrucosa Colubrina texensis (Rhamnaceae) Antimitotic, antileukaemic, antitumour... 

A number of naturally derived agents have been entered into clinical trials which have been terminated due to lack of efficacy or unacceptable toxicity. One of these, maytansine (51), was isolated in the early 1970s from the Ethiopian plant, Maytenus serrata (Hochst. ex A.Rich.) R. Wilczek. " Despite very low yields (2 x 10 % based on plant dry weight), its extreme potency in testing against cancer cell lines prompted the production of sufficient quantities to pursue preclinical and clinical development. 

The structures of two novel spermidine alkaloids celacinnine and celallocinine, obtained from the twigs of Maytenus serrata, have been shown to be (31) and... 

The full account of the work by the late S. M. Kupchan and his collaborators on the maytansinoids includes details of the isolation, structural elucidation, and chemical inter-relationships of those novel ansa macrolides. Of the ten macrolides isolated from Maytenus serrata, only maytansine [35 =... 

In the course of total synthesis of maytansine 1 (Fig. 8.1), an ansa-macrocyclic lactam from Maytenus serrata, M. buchananii, etc., the heteroconjugate addition [1-3] of methyllithiiun to the pyranosyl heteroolefin such as 2 (Fig. 8.2) proceeded with the complete acyclic stereoselection [1]. The authors explained the high diastereoselective C-C bond formation by efficient conformational and chelational control. 

Maytansine Maytenus diversifolia, M. confertifbrus, M. hookeri, M. serrata... 

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