Mature B-cell neoplasms

Lymphoid neoplasms are divided into three main categories B cell neoplasms, T/NK cell neoplasms, and Hodgkin lymphoma. The B and T/NK cell neoplasms are further divided into precursor B and mature B cell neoplasms and into precursor T and mature T/NK cell neoplasms, respectively. The mature B cell and T/NK neoplasms consist of a variety of different neoplastic lymphoid entities, which can be grouped based on primary clinical presentation or based on median survivals without treatment reflecting biologic behavior. However, due to the large number of separate entities, only the more common lesions will be discussed. For information concerning the entities not discussed here or for more in-depth information, the... 

H10. Harris, N. L., Mature B-cell neoplasms Introduction. In World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (E. S. Jaffe, N. L. Harris, H. Stein, and J. W. Vardiman, eds.), pp. 121-126. IARC Press, Lyon, 2001. 

Precursor B-cell neoplasm Precursor B-lymphoblastic leukemia/lymphoma Mature (peripheral) B-cell neoplasms B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma... 

IFN-a Family. There are 14 human genes that comprise the IFN-a family. These genes generally encode mature polypeptides with either 165 or 166 amino acids and have a 15% to 25% variation in primary amino-acid sequence. Minor variants consisting of one or two amino-acid differences account for multiple alleles. Thirteen separate proteins are expressed from these 14 genes (Table 7.1), each with a different profile of antiviral and antiproliferative activity [40,41]. Evidence for cell specificity of IFN-a subtypes has been reported. For example, IFN-al has greater antiproliferative effects on B-cell neoplasms, whereas IFN-a2 is more specific for other malignancies [42]. When assayed on human cells, IFN-al has less antiviral activity than IFN-a2 [43]. Nevertheless, IFN-al has potent antiviral activity in bovine-, feline-, and primate-derived cells [44]. Fur-... 

B- and T-cell neoplasms are divided into precursor disorders (lymphoblastic leukemias and lymphomas) with normal counterparts in the earliest bone marrow and thymus compartments, and mature, or peripheral, malignancies akin to normal extrathymic, nodal, splenic, or circulating lymphocytes. Discussion is focused on those malignancies commonly diagnosed using immunohistochemistry (i.e., solid tumors). 

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