Matrix,extracellular biodegradable

Hong Y, Takanari K, Amoroso NJ, Hashizume R, Brennan-Pierce EP, Freund JM, et al. An elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair. Tissue Eng Part C Methods February 2012 18(2) 122-32. 

Nanofibrillar chitin hydrogels are biodegradable, biocompatible, and nontoxic, and thus show promise for biomedical applications. The protonation of amino groups on the surface of chitin allows its application in wound dressings due to the antimicrobial properties of cationic gels [130]. Polymeric fibers that mimic the structure and function of the extracellular matrix are also of interest in tissue engineering and cell culture. Chitin nanofibers can promote cell attachment and show potential as extracellular matrix mimics [29, 125]. 

Hong, Y, Huber, A., Takanari, K., Amoroso, N.J., Hashizume, R., Badylak, S.F., Wagner, W.R., 2011. Mechanical properties and in viva behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold. Biomaterials 32, 3387-3394. 

Liao, J., Guo, X., Nelson, D., Kasper, F.K., Mikos, A.G., 2010. Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomater. 6, 2386-2393. 

In many cases, the matrices and scaffolds of these implants would ideally be made of biodegradable pol5miers. These pol5mciers should mimic the functions of the extracellular matrix (ECM). This is a soft, tough and elastomeric proteinaceous network that provides mechanical stability and structural integrity to tissues and organs. 

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