Masticadienolic acid

Oleanolic acid, 3 epi masticadienolic acid, 3 epi isomasticadienolic acid C30H48O3... 

O acetyl 2 epi masticadienolic acid, 3 O acetyl 2 epi isomasticadienolic acid C32H50O4... 

Several studies have dealt with the problem of discriminating between mastic and dammar, and three marker compounds of mastic have been identified moronic, masticadienonic and acetyl masticadienolic acids [42], The chemical structure of (iso)masticadienonic acid and 3-0-acetyl-3-epi(iso)masticadienonic acid is characterized by a side chain, as for dammarane molecules, but with a carboxylic acid end group (Table 12.1). Under pyrolysis conditions this side chain is susceptible to cleavage as demonstrated by the presence, among the pyrolysis products of mastic, of 2-methyl-pent-2,4-dienoic acid, that perfectly matches with the chemical structure of the side chain end. In addition 3-(9-acetyl-3-epi-(iso)masticadienolic acid also loses the acetyl group and, in contrast to masticadienonic acid, is not detected at all. 

Shinol (3(3-Masticadienolic acid) 103 Schinus terebinthifolius berries PLA2 [126]... 

Four new acids, masticadienolic acid (61) and its 3-epimer (62) and isomastic-adienolic acid (63) and its 3-epimer (64), have been isolated from the galls of Pistacia terebinthus. The confusion which has surrounded the elemi acids has... 

Anti-PLA2 activity against three different forms of PLA2 was reported by Jain et al. [50] for two lanostanes isolated from Schinus terebinthifolius (Anacardiaceae) and identified as masticadienoic and masticadienolic acids. According to the authors, these compounds have a novel pharmacophore that interacts with the catalytic site of the enzyme. The two substances differed significantly in their inhibitory potencies in relation to the PLA2 from different sources. Masticadienolic acid, also called schinol, at 0.016... 

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