Mass spectrometry folic acid

The first liquid chromatography-mass spectrometry (LC-MS) method was developed by Stokes and Webb (1999). Here, folate was separated using reversed-phase chromatography, detected in a single ion monitoring (SIM) mode and quantified using external standards [25]. These authors successfully identified and determined folic acid, tetrahydrofolate, 5-methyltetrahydrofolate, and formyltetrahydrofolate in multivitamins and foods. 

Chandra-Hioe, M. V, BucknaU, M. R, and Arcot, J. 2013. Folic acid-fortified flour Optimised and fast sample preparation coupled with a vahdated high-speed mass spectrometry analysis suitable for a fortification monitoring program. Food Anal. Methods. DOI 10.1007/S12161-012-9559-3. 

Pawlosky, R., Flanagan, V., and Pfeiffer, C. 2001. Determination of 5-methyltetrahydro-folic acid in human serum by stable-isotope dilution high-performance liquid chromatography-mass spectrometry. Anal. Biochem. 298 299-305. 

C-labeled folic acid with accelerator mass spectrometry. Analtyical Biochemistry, 269, 348-352. 

Jung, M., Kim, B., Boo, D.W., and So, H.-Y., 2007. Development of isotope dilution-liquid chromatography/tandem mass spectrometry as a candidate reference method for the determination of folic acid in infant milk formula. Bulletin of the Korean Chemical Society. 2007 745-750. 

Nelson, B.C., Sharpless, K.E., and Sander, L.C., 2006. Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chro-matography/tandem mass spectrometry. Journal of Chromatography T. 1135 203-211. 

Phillips, K.M., Ruggio, D.M., Ashraf-Khorassani, M., Eitenmiller, R.R., Cho, S., Lemar, L.E., Perry, C.R., Pehrsson, P.R., and Holden, J.M., 2010. Folic acid content of ready-to-eat cereals determined by liquid chromatography-mass spectrometry comparison to product label and to values determined by microbiological assay. Cereal Chemistry. 87 42-49. 

Thomas PM, Flanagan VP, Pawlosky RJ. Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution—mass spectrometry. J Agri Food Chem 2003 51 1293-6. 

MS AA and folic acid are determined. Quantitative detection is achieved by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in negative ion mode using the method of standard addition 5.9 ng g-> No data 0.2-3.1 Pharmaceuticals 2013 253... 

Bhandari, D., V. Kertesz, and G. J. Van Berkel. 2013. Rapid quantitation of ascorbic and folic acids in SRM 3280 multivitamin/multielement tablets using flow-injection tandem mass spectrometry. Rapid Commun. Mass. Spectrom. 27 163-168. 

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