Mass Spectrometry Basics LSIMS

The basic principles of fast-atom bombardment (FAB) and liquid-phase secondary ion mass spectrometry (LSIMS) are discussed only briefly here because a fuller description appears in Chapter 4. This chapter focuses on the use of FAB/LSIMS as part of an interface between a liquid chromatograph (LC) and a mass spectrometer (MS), although some theory is presented. [Pg.81]

Mass Spectrometry (LSIMS), and Continuous-Flow FAB of Chlorophylls F4.5.1 Basic Protocol 2 LC/MS Using Atmospheric Pressure Chemical... [Pg.921]

The classicaf FAB ionization technique consists in the bombardment of the sample dissolved in a nonvolatile, viscous, and polar liquid (the matrix) with neutral xenon atoms. However, a much more popular version is Liquid-matrix Secondary-ion Mass Spectrometry (LSIMS) in which the sample solution is bombarded with heavy ions, usually Cs+ or Xe+. Basic information about FAB and LSIMS can be found in mass spectrometry monographs [3, 4]. Comprehensive reviews on the application of FAB for analyzing biomolecules [5-7] and, specifically, saccharides and glycoconjugates [8] are also available. [Pg.257]

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