Mass spectrometric analysis sulfate desorption

Laremore, T. N. et al.. Matrix-assisted laser desorption/ionization mass spectrometric analysis of uncomplexed highly sulfated oligosaccharides using ionic liquid matrices. Anal. Chem., 78,1774,2006. 

In recent years, several techniques have been developed for mass spectrometry, whereby samples are ionized and analysed from a condensed phase, without prior volatilization. These desorption techniques have permitted the extension of mass spectrometric analyses to sulfate and glutathione conjugates, as well as to underivatized and labile glucuronic acid conjugates. Primary among these techniques are field desorption 6, plasma desorption (7), laser desorption (8), fast atom bombardment (or secondary ion mass spectrometry with a liquid sample matrix) ( ) and thermospray ionization ( O). The latter can also serve to couple high pressure liquid chromatography and mass spectrometry for analysis of involatile and thermally labile samples. 

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