Markers oncogenes

Bakkus, M.H., Brakel-van Peer, K.M., Adriaansem, H.J., Wierenga-Wolf, A.F., van den Akker, T.W., Dicke-Evingep M.J., and Benner, R. (1989) Detection of oncogene expression by fluorescent in situ hybridization in combination with immunofluorescent staining of cell surface markers. Oncogene 4,1255-1262. 

D8. Duffy, M. J., Cellular oncogenes and suppressor genes as prognostic markers in cancer. Clin. Biochem. 26, 439-447 (1993). 

Slebos RJ, Kibbelaar RE, Dalesio O et al. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N EnglJ Med 1990 323 561-565. 

Fixemer, T., Wissenbach, U., Flockerzi, V. and Bonkhoff, H., 2003, Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer a novel prognostic marker for tumor progression. Oncogene 22, 7858-61. 

Evidence for the link between PKC activation and cell proliferation was initially provided by the demonstration that two intracellular events associated with cell replication - a rise in cytosolic pH and the expression of the proto-oncogenes c-fi/s and c-tnyc - are controlled by PKC PKC stimulates the membrane bound Na /H exchange mechanism in smooth muscle which extrudes intracellular H in exchange for extracellular Na this leads to a rise in intracellular pH, a prerequisite for cellular DNA replication (Mitsuka and Berk, 1991). c-fbs and c-myc are proto-oncogenes whose transcription to mRNA is one of the earliest markers of cell proliferation they encode for proteins, found in the cell nucleus, which initiate the sequence of events leading to DNA synthesis (Rozen-gurt, 1991). 

---