Marine purine alkaloids

Dimethylisoguanine (4) and its conjugate acid 1,3-dimethylisoguaninium (S) have been found in several marine organisms as summarized in Table 9.1. These purine alkaloids w ere first identified in the marine sponge Amphimedon viridis [6,7] and later in A. paraviridis [8]. Copp and cow orkers have also reported the isolation of... 

This series in heterocychc chemistry is being introduced to collectively make available critically and comprehensively reviewed hterature scattered in various journals as papers and review articles. All sorts of heterocyclic compounds originating from synthesis, natural products, marine products, insects, etc. will be covered. Several heterocyclic compounds play a significant role in maintaining life. Blood constituents hemoglobin and purines, as well as pyrimidines, are constituents of nucleic acid (DNA and RNA). Several amino acids, carbohydrates, vitamins, alkaloids, antibiotics, etc. are also heterocyclic compounds that are essential for life. Heterocyclic compounds are widely used in clinical practice as drugs, but all applications of heterocyclic medicines can not be discussed in detail. In addition to such applications, heterocyclic compounds also find several applications in the plastics industry, in photography as sensitizers and developers, and the in dye industry as dyes, etc. 

A methodology for the synthesis of analogs of asmarine, marine alkaloids with a unique tetrahydro[l,4]diazepino[l,2,3-g,h]purine 120 (THDAP) strueture has been developed. Three cyclization methods were applied for the preparation of the 9,9-disubstituted 10-hydroxy-THDAP system aminomereurization, iodocyclization and acid-catalyzed cychzation <05JOC199>. A series of 2-phenyl[l,2,3]triazolo[l,2-a][l,2,4]benzotriazin-l,5-diones 121 have been synthesized and identified as affinity central benzodiazepine-receptor ligands <05JMC2936>. 

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