Marijuana fluid

The body is composed of about 70% water by weight. The fluid portion of the blood (plasma) accounts for 6 liters or about 4% of that total. Intracellular water constitutes about 41 % while interstitial (between cells) fluid is 13%. The rest is extracellular. Therefore solubility in water will be an important factor in drug distribution. Fat depots within adipose and other fatty tissues are also important in that they can sequester lipophilic molecules and release them very slowly back into the general blood circulation. This is the case with tetrahydrocannabinol (THC), the psychoactive component of marijuana. It shows two periods of presence in the blood the first immediately after consumption and the second a more lingering presence for up to 27 days after use. 

Keywords Cannabinoids Pharmacokinetics Tetrahydrocannabinol Cannabidiol Absorption Distribution Metabolism Excretion Interpretation Oral fluid Sweat Hair Plasma Urine Alternate matrix Marijuana... 

Cone EJ, Lange R, Darwin WD (1998) In vivo adulteration excess fluid ingestion causes false-negative marijuana and cocaine urine test results. J Anal Toxicol 22 460-473... 

Niedbala RS, Kardos KW, Fritch DF, Kardos S, Fries T, Waga J (2001) Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana. J Anal Toxicol 25 289—303... 

Saliva. Testing of oral fluids is becoming increasingly common because of its convenience for random testing, and it is more resistant to adulteration than urine samples. Saliva testing can detect cocaine, amphetamine, methamphetamine, marijuana, bezodi-azepines, PGP, opiates, and alcohol if the substance was ingested between six hours and three days before the test was administered. 

Because of the sensitivity of mass spectrometry, it is often used to detect the presence of drugs in blood, urine, or other biological fluids. Tetrahydrocannabinol (nominal mass 314), a component of marijuana, exhibits two strong fragment ions at m/z 246 and... 

The first patient was a 20-year-old man who presented with nausea, vomiting and severe epigastric pain. He was initially diagnosed with pancreatitis because of a mildly elevated serum amylase level and history of heavy alcohol use. He was using marijuana daily for 2 years. With the use of intravenous (IV) opioids and fluids his symptoms did not improve even after his laboratory values normalised. He insisted on taking several showers... 

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