Mannose-binding lectins

Matsushita M, Hijikata M, Ohta Y, Iwata K, Matsumoto M, Nakao K et al. Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL. Arch Virol 1998 143[4] 645—651. 

Lectin pathway, stimulated by binding to a lectin. Lectins belong to a family of proteins called collectins, which are present in blood and bind to bacteria. One lectin, known as the mannose binding lectin (MBL), binds to a sequence of mannose sugars that are part of the carbohydrate on the cell surface of some bacteria. It is the lectin-bacteria complex that activates one of the complement proteins. The components of the pathway are prefixed with a C and a number. 

Turner, M. W. (2003). The role of mannose binding lectin in health and disease. Mol. Immunol. 40, 423-429. 

Bourne, Y., Zamboni, V., Barre, A., Peumans, W.J., Van Damme, E.J., and Rouge, P, Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins, Structure (London), 7, 1473-1482, 1999. 

Figure 15.1 Complement activation pathways. The classical, lectin and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. Ab = antibody, Ag = antigen, Cl-INH = Cl inhibitor, MAC = membrane attack complex, MASP = MBL-associated serine protease, MBL = mannose-binding lectin, P = properdin. Overbar indicates activation.

Turner MW Mannose-binding lectin The pluripotent molecule of the innate immune system. Immunol Today 1996 17 532-540. 

Mannan-binding lectin 59 Mannose-binding lectin, MBL, MBP, rarf(p28)... 

O. Bertrand, S. Cochet, and J. P. Cartron, Expanded bed chromatography for one-step purification of mannose binding lectin from tuhp bulbs using mannose im-mobihzed on DEAE Streamline, J. Chromatogr. A 822 19 (1998). 

Turner MW, Hamvas RM. Mannose-binding lectin structure, function, genetics and disease associations. Science 2001 29 2370-6. 

C-reactive protein, interferons, mannose binding lectin cytokines... 

---