Mannich reactions of cyclohexanone

DFT has been used to probe the effects on stereoselectivity of an or-amino acid catalyst on a Mannich reaction of cyclohexanone and a -amino acid catalyst as well." ... [Pg.7]

A general bismuth-triflate-catalyzed direct-type Mannich reaction of cyclohexanone with imines derived from various benzaldehydes and anilines was reported. P-Aminocarbonyl compounds are obtained efficiently in the presence of 5 mol%... [Pg.27]

Three-component Mannich reactions of cyclohexanone and anilines with aromatic aldehydes, in the presence of HjO, have been promoted by amphiphilic isosteviol-proline organocatalysts with excellent de and eef DFT calculations indicate that the proline-catalysed single and double Mannich reactions between acetaldehyde and A-Boc imines, to give (5) and (5,5)-conformation products, respectively, are stereochemically controlled by hydrogen bonding." High enantioselectivity has been reported for L-proline-catalysed addition of aldehydes to 2-aryl-3//-indol-3-ones," ... [Pg.5]

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