Mammalian cells viral glycoproteins

Mammalian cells synthesize a vast range of biopharmaceuticals that cannot or hardly be expressed by recombinant microbial techniques, including viral vaccines, antibodies for diagnostics, and therapeutic proteins (recombinant glycoproteins, antibodies) [14, 15]. 

The initial step in the sequence of events leading to influenza virus infections in mammalian hosts is mediated by the multiple attachment of virus particles to host sialoside receptors in the nasopharynx [41]. These receptors consist largely of cell surface sialylated glycoproteins and gangliosides. The subsequent steps involve receptor-mediated endocytosis with ensuing release of the viral nucleo-plasmid. The first event responsible for the receptor-virus interaction is therefore an attractive target for both antiviral and related microbial intervention. 

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