Malonic acid, -, dimethyl ester

Malonic acid dimethyl ester, 2-(l-thienyl)-X-ray, 4, 724 (78CC83)... 

The application of 3-aminopropyl phosphine (3) [41,46] as a building block for incorporation into -COOH functionalized frameworks provides an excellent example of the utility of preformed primary phosphine frameworks (Scheme 8) [46]. The reactions involved Michael addition of ferf-butyl acrylate to malonic acid dimethyl ester to produce the intermediate adduct, 2-methoxycarbonyl-pentanedioc acid 5-ferf-butyl ester 1-methyl ester, which upon treatment with trifluro-acetic acid (TFA) produced the corresponding diester acid,2-methoxy-carbonyl-pentanedioic acid 1-methyl ester, in near quantitative yield. It is remarkable to note that the reaction of NH2(CH2)3PH2 (3) with the diester acid is highly selective as the -COOH group remained unattacked whereas the reaction occurred smoothly and selectively at the -COOMe groups to pro-... 

One of the most recent developments in the field of Ni-catalyzed reactions of alkyl halides with organozinc derivatives is a study of Terao et al.411 They reported the use of three additives in the couplings 1,3-butadiene, N,N-bis(penta-2,4-dienyl)benzylamine 308a, and 2,2-bis(penta-2,4-dienyl)malonic acid dimethyl ester 308b. Addition of tetraene 308b to the reaction mixtures significantly increased the product yields (Scheme 157). The remarkable effect of these additives was explained by the formation of the bis-7r-allylic complex 309 as the key intermediate (Scheme 158). 

Butanoic acid, methyl ester Malonic acid, dimethyl ester 1,1-Dimethylpropanoic acid, 1,1-dimethylester... 

Dimethyl malonate Malonic acid, dimethyl ester (8) Propanedioic acid, dimethyl ester (9) (108-59-8)... 

Isobutyl malonic acid dimethyl ester Hydrogen chloride... 

The stereogenic center at C20 is introduced by enantioselective enzymatic hydrolysis of MOM-protected malonic acid dimethyl ester derivative 60 (Scheme 10) with pig liver esterase (PLE). The asymmetric compound 61 is obtained in 90 % yield and 98 % ee. Amide formation with Mu-... 

A solution of 2-(2-bromo-2-methylpropylidene)malonic acid dimethyl ester (20 mmol) (or its 2-chloro derivative) in dry EtjO (25 mL) was added dropwise to a suspension of LiAlH (50 mmol) in dry EtjO (25 mL) with stirring at 0°C. After stirring for an additional 12 h, the mixture was poured out into a mixture of EtjO (50 mL) and H O (50 mL). The organic layer was separated and the aqueous phase was extracted with EtjO (2x 100 mL). The combined ethereal extracts were dried (MgS04) and the solvent evaporated in vacuo. The crude cyclopropane was purified by vacuum distillation and/or recrystallization (CCVhexane) yield 71 %. 

Malonic acid, dimethyl ester. See Dimethyl malonate... 

C6H10O4 2-methyl-malonic acid dimethyl ester 609-02-9... 

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