Maloney murine leukaemia virus

The most commonly employed (recombinant deficient) retrovirus used in this regard has been derived from the Maloney murine leukaemia virus (MoMuLV). 

More recently, various modifications have been introduced to this basic retroviral system. The inclusion of the 5 end of the gag gene is shown to enhance levels of vector production by up to 200-fold. Additionally, specific promoters have been introduced in order to attempt to control expression of the inserted gene. Most work has focused upon the use of tissue-specific promoters in an effort to limit expression of the desired gene to a specific tissue type. The most commonly employed (recombinant-deficient) retrovirus used in this regard has been derived from the Maloney murine leukaemia virus (MoMuLV). 

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