Malignant tumor, therapeutic applications

The major problem of gene therapy is the low transduction efficiency in vivo. For the application to cancer this problem is exacerbated by the inefficient vascularization and high interstitial pressure in malignant tumors, which limit the accessibility for any kind of vector. One possibility to address this problem is the use of viruses that are able to replicate in vivo and thereby spread throughout the tumor tissue. This approach is not only useful for the improved delivery of therapeutic proteins but seems particularly appealing if combined with the intrin-... 

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