MALDI ionization-mass spectroscopy

Mass spectra are used to determine molecular weights and molecular composition (from the parent or molecular ion) and to obtain structural information from the fragmentation of the molecular ion into daughter ions. Electrospray ionization (ESI-MS) and matrix-assisted laser desorption ionization (MALDI-MS) mass spectroscopy can be used to obtain structural information about macromolecules, including proteins, polymers, and drug-DNA complexes. 

The low volatility of ILs makes them useful as solvents working under high vacuum, and together with their more amorphous solid analogs they are convenient in matrix-assisted laser-desorption/ ionization-mass spectroscopy (MALDI-MS) analysis.103104... 

The majority of reports have used electrospray ionization mass spectroscopy (ESI-MS) as an analytical detection method because of its sensitivity and the soft namre of its ionization procedure, which generally only leads to the detection of the molecular ions of the positive library members. Many separation techniques have been coupled to ESI-MS, including affinity chromatography (49), size exclusion chromatography (50, 51), gel filtration (52), affinity capillary electrophoresis (53-58), capillary isoelectric focusing (59), immunoaffinity ultrafiltration (60), and immunoaffinity extraction (61). ESI-MS has also been used alone (62) to screen a small carbohydrate library. Other examples reported alternative analytical techniques such as MALDI MS, either alone (63, 64) or in conjunction with size exclusion methods (65), or HPLC coupled with immunoaffinity deletion (66). 

MALDI-MS refers to matrix-assisted laser desorption-ionization mass spectroscopy, It is also called MALFI-TOF, because the mass spectrometer is a time-of-flight version. In this technique, the polymer is mixed with a molar excess of a salt, for cationization, and deposited on a probe surface. A UV laser is pulsed... 

MALDI-MS, matrix-assisted laser desorp-tion/ionization mass spectroscopy. 

Matrix-assisted laser desorption—ionization mass spectroscopy is a convenient method for rapid and sensitive structural analysis of oligosaccharides (Harvey 1999). It was observed that MALDI TOE TOF mass spectrometric analysis reveal a series of masses (m/z) corresponding to pentose and hexose sugars... 

Mass spectrometry. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectroscopy has been used to determine fetd/fetc in S and MMA polymerization. Chains formed by disproportionation and chains formed by combination form two distinct distributions. 

Mass spectroscopy is a useful technique for the characterization of dendrimers because it can be used to determine relative molar mass. Also, from the fragmentation pattern, the details of the monomer assembly in the branches can be confirmed. A variety of mass spectroscopic techniques have been used for this, including electron impact, fast atom bombardment and matrix-assisted laser desorption ionization (MALDI) mass spectroscopy. 

Considering these situations, the observation of molecular weights, particularly by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MASS), is essential [33]. The operation is simple and enables us to observe the molecular ion peaks of CPOs with molecular weights exceeding 10,000. The quahty of the measurement is strongly dependent on the choice of the matrix. Therefore, the search for the best matrix for each CPO should be pursued. 

MALDI MCM-41 MCR MD ME MEM MI MPM MRI MS MVA Matrix-assisted Laser Desorption/Ionization Mobile Crystalline Material-41 Multivariate Curve Resolution Molecular Dynamics Matrix-enhanced Magnetic Force Micrscopy Multivariate Image Multiphoton Microscopy Magnetic Resonance Imaging Mass Spectroscopy Multivariate Analysis... 

Matrix-assisted laser-desorption ionization time-of-fiight (MALDI-TOF) mass spectrometry can be used to detect sequence polymorphisms. With mass spectroscopy, no label is necessary because the alleles differ in mass. After... 

SEC, size exclusion chromatography. MALDI-TOF-MS, matrix-assisted laser desorption/ ionization time-of-flight mass spectroscopy. 

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