Magnusson

Karlstrdms, M., Magnusson Seger, M., Crack estimation with linear filtered tomosynthesis , ISSN 1400-3902, Dept of Electrical Engineering Linkoping, Sweden (1998). 

The 1,6-difunctional hydroxyketone given below contains an octyl chain at the keto group and two chiral centers at C-2 and C-3 (G. Magnusson, 1977). In the first step of the antithesis of this molecule it is best to disconnect the octyl chain and to transform the chiral residue into a cyclic synthon simultaneously. Since we know that ketones can be produced from add derivatives by alkylation (see p. 45ff,), an obvious precursor would be a seven-membered lactone ring, which is opened in synthesis by octyl anion at low temperature. The lactone in turn can be transformed into cis-2,3-dimethyicyclohexanone, which is available by FGI from (2,3-cis)-2,3-dimethylcyclohexanol. The latter can be separated from the commercial ds-trans mixture, e.g. by distillation or chromatography. 

Magnusson, B., Bergman, M., Bergman, B. and Soremark, R. Nickel Allergy and Nickel Containing Dental Alloys , Scandinavian Journal of Denial Research, 90, 163-167 (1982)... 

Concerning sensitization, sulfosuccinates have been proven nonsensitizing according to the Magnusson-Kligman test [97]. 

U. Nilsson, A. Wendler, and G. Magnusson, Acta Chem. Scand., 48 (1994) 356-361, and references therein. 

Magnusson, O.T. et al., Quinone biogenesis structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone, Proc. Natl. Acad. Sci. USA, 101, 7913, 2004. 

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