Magnetic resonance methods, for

Nuclear Magnetic Resonance Method for Relative Configuration Determination... 

A nuclear magnetic resonance method for chlorpromazine has been reported [178]. For tablets, capsules, and bulk chemical, the sample is shaken with CHCI3 containing cyclohexane or piperanol as an internal standard. For injectable solutions, tetramethylammonium bromide was used as the internal standard. The NMR spectrum was recorded between 0 and 7.0 ppm, and the drug resonance at 2.7 ppm (relative to TMS) measured. The signals for the respective internal standards were at 1.5, 6.0, and 3.3 ppm. 

Li, C.-Y. et al., Efficient IH nuclear magnetic resonance method for improved quality control analyses of ginkgo constituents, J. Agric. Food Chem., 52, 3721, 2004. 

Mills, B.L. and van der Voort, F.R. 1981. Comparison of the direct and indirect wide-line nuclear magnetic resonance methods for determining solid fat content. J. Am. Oil Chem. Soc. 58 776-778. 

Tinsley, F. C., Taicher, G. Z. and Heiman, M. L. (2004) Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res 12, 150-160. 

Mansour et al. [46] developed a simple, rapid efficient quantitative proton magnetic resonance method for the determination of mefenamic acid in Ponstan capsules. The method is based on a comparison between the sum integrals of the two methyl singlets of mefenamic acid and that integral of the sharp singlet of / -methoxybenzylidenemalononitrile (internal standard). The method gave accurate and reproducible results. 

Mildvan, A.S., Harris, T.K., and Abeygunawardana C. (1999) Nuclear magnetic resonance methods for the detection and study of low-barrier hydrogen bonds on enzymes, in Schramm, V. L. and Purich, D. L. (eds.), Methods in Enzymology, 308, Enzyme Kinetics and Mechanism, Part E, Academic Press, San Diego, pp. 219-247. 

Palmer, A. G., 3rd, Kroenke, C. D., and Loria, J. P. (2001). Nuclear magnetic resonance methods for quantifying microsecond-to-miUisecond motions in biological macromolecules. Methods Enzymol. 339, 204-238. 

Mills, B.L., and F.R. VanDeVoort, Comparison of the Direct and Indirect Wide Line Nuclear Magnetic Resonance Methods for Determining Solid Fat Content, Ibid. 58 776-778 (1981). 

Mikita, M. A., Steelink, C., and Wershaw, R. L. (1981). Carbon-13 enriched nuclear magnetic resonance method for the determination of hydroxyl functionality in humic substances. Anal. Chem. S3, 1715-1717. 

Dyson HJ, Wright PE (2001) Nuclear magnetic resonance methods for elucidation of structure and dynamics in disordered states. Methods Enzymol 339 258-270... 

NMR spectra of (a) a soil humic acid (b) a groundwater fulvic acid (c) a mixture of C-methylated reference compounds (1) pentamethylquercetin (2) glycerol dimethyl ether (3) methyl benzoate (4) methyl pentanoate. Reprinted with permission from Mikita et al., Carbon-13 Enriched Nuclear Magnetic Resonance Method for the Determination of Hydroxyl Functionality in Humic Substances, Anal. Chem. 53, 1715-1717. Copyright 1981, American Chemical Society. 

To place these developments in perspective, some account will be given of the invention of magnetic resonance methods for condensed matter and of the various types of apparatus that were available, especially for MR where there has been substantial improvement in instrumentation with time. (We shall abbreviate nuclear magnetic resonance by NMR" and electron paramagnetic resonance by "EPR". We prefer the latter designation to electron spin resonance, because electron orbital as well as spin moments may be involved.) Since many readers may not be familiar with the principles of magnetic resonance, qualitative explanations of basic aspects are included. Emphasis will be on work in the United States, but some contributions from elsewhere will be mentioned. 

For discussion of magnetic resonance methods for determining the rates of electron exchange between radicals of the type we have considered in this section, one may consult, among others, the recent book of Caldin" or the chapter of Fraenkel". ... 

R435 R. Novoa-Carballal, E. Fernandez-Megia, C. Jimenez and R. Riguera, Nuclear Magnetic Resonance Methods for Unraveling the Spectra of Complex Mixtures , Nat. Prod. Rep., 2011, 28, 78. 

PMMA, indicating that the confonnation of the chain unit carrying the spin label depends on the host polymer and solvent. Our results are in good agreanent with NMR data, which are presented in Fig. 5 by dashed line. To our knowledge, snch qnantita-tive agreement between the data of two different magnetic resonance methods for polymer dynamics has not been reported yet. 

Griffiths JM and Griffin RG (1993) Nuclear magnetic resonance methods for measuring dipolar couplings in rotating solids. Analytica Chimica Acta 283 1081-1101. 

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