Magnetic resonance imaging dendrimer

Kobayashi, H., Kawamoto, S., Star, R.A., Waldmann, T.A., Tagaya, Y., and Brechbiel, M.W. (2003) Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent. Can. Res. 63, 271-276. 

Gadolinium-dendrimer conjugates have been used as blood pool contrast agents in vivo for nuclear magnetic resonance imaging (MRI) of tumors [65]. The efficacy of the conjugates in such applications is dependent on their biodistribution properties, and these properties vary as a function of dendrimer molecular weight and chemical composition [50]. Dendrimer architecture and synthesis... 

Drug and DNA delivery, photodynamic therapy, boron neutron capture therapy, and magnetic resonance imaging are some areas in which appropriately functionalized dendrimers are being evaluated (Jang and Kataoka 2005 Svenson and Tomalia 2005 Yang and Kao 2006). In one particularly nice example, polylysine... 

Like PAMAM dendrimers, polylysine dendrimers are largely characterised by amide bonds. They attracted interest as potential therapeutic agents for use in boron neutron capture therapy and in magnetic resonance imaging (MRI) (see Chapter 8), since dendritic polylysines apparently have a lower toxicity than their linear counterparts. The polylysine shown in Fig. 4.10 with a total of 80 terminal boron atoms in the carborane units and a dansyl group was designed specifically for boron neutron capture therapy [20]. 

Micellane series registered trademark (University of South Florida) descriptor of the all-hydrocarbon based dendrimers MRI magnetic resonance imaging NBS N-bromosuccinimide... 

E. C. Wiener, V. V. Narayanan, Magnetic Resonance Imaging Contrast Agents Theory and the Role of Dendrimers, in Advances in Dendritic Macromolecules, G. R. Newkome, Ed., pp. 129-247, Elsevier Science, Kidlington, Oxford, UK, 2002. 

Villaraza, A.J.L., Bumb, A., Brechbiel, M.W. Macromolecules, Dendrimers, and Nanomaterials in Magnetic Resonance Imaging The Interplay between Size, Function, and Pharmacokinetics. Chem. Rev. 110(5), 2921-2959 (2010). doi 10.1021/Cr900232t... 

Wiener, E. C., Brechbiel, M. W., Brothers, H., Magin, R. L., Gansow, O. A., Tomalia, D. A., Lauterbur, P. C., 1994, Dendrimer-based metal chelates a new class of magnetic resonance image contrast agents. Magn. Reson. Med. 13 1-8. 

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