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Blood pool contrast agents

Gadolinium-dendrimer conjugates have been used as blood pool contrast agents in vivo for nuclear magnetic resonance imaging (MRI) of tumors [65]. The efficacy of the conjugates in such applications is dependent on their biodistribution properties, and these properties vary as a function of dendrimer molecular weight and chemical composition [50]. Dendrimer architecture and synthesis... [Pg.552]

Weichert JP, Lee FT, Chosy SG, Longino MA, Kuhlman JE, Heisey DM, Leverson GE (2000) Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits. Radiology 216 71... [Pg.199]

Because gas bubbles a few microns in diameter do not normally leave the vasculature, they constitute true blood pool contrast agents, that is, agents that, when submitted to US, light up the blood, hence the blood vessels and the chambers of the heart. The dose of gas needed for effective contrast enhancement is very small, typically on the order of a fraction of a milliliter, dispersed within some 10 bubbles a few microns in diameter. The total amount of RFC administered to a patient is on the order of milligrams. This dose is minuscule when compared with the grams of contrast agents currently used in X-ray or MRI. The RFC is subsequently exhaled by the patient unchanged within minutes. [Pg.464]

Keywords. Blood-pool contrast agents, Rotational motion, Relaxivity, Gd3+ chelates, Iron oxide particles, NMRD, EPR, NMR... [Pg.201]

Fig. 3. Distribution and elimination of different sized PCAs. Note difference in permeability (pore size) of endothelial capillary and glomerular membrane ECCA = extracellular contrast agent BPCA = blood-pool contrast agent. Adapted from [10] with permission... Fig. 3. Distribution and elimination of different sized PCAs. Note difference in permeability (pore size) of endothelial capillary and glomerular membrane ECCA = extracellular contrast agent BPCA = blood-pool contrast agent. Adapted from [10] with permission...
Turetschek K, Floyd E, Helbich T, Roberts TP, Shames DM, Wendland MF, et al. MRI assessment of microvascular characteristics in experimental breast tumors using a new blood pool contrast agent (MS-325) with correlations to histopathology. J Magn Reson Imaging 2001 14 237-242. [Pg.218]

Kroft, L.l.M. and de Roos, A. (1999) Blood pool contrast agents for cardiovascular MR imaging. Journal of Magnetic Resonance Imaging, 10, 395-403. [Pg.431]

Mohs AM, Lu ZR. Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging status and clinical potential. Expert Opin. Drug Deliv. 2007 4 149-164. [Pg.1096]

Other polymers have also been investigated as blood-pool contrast agents. Revel et al. (920) used an iodinated polymer consisting of a carboxymethyldextran with a triiodinated benzoic acid substituent. The iodinated polymer had a mean molecular weight of 32,000 Da, ranging from 10 to 10 Da and contained 24 mg I per 100 mg of powder. An intravenous... [Pg.577]

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See also in sourсe #XX -- [ Pg.525 ]



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Blood pool agents

Blood pooling

Contrast agent

Contrasting agent

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