Morphine Magnesium sulfate

In rats, papaverine had a choleretic effect (271). It caused relaxation of the duodenum, of the sphincter of Oddi, and of the muscles of the bile duct (272-277). It paralyzed the spasmogenic effect of morphine on these structures. Papaverine (0.36 g) in combination with 100 ml of 60% sorbitol, administered to man by means of a duodenal probe, showed a higher choleretic and a lower cholecystokinetic effect than a 30% solution of magnesium sulfate (277). 

The antidote for magnesium sulfate overdosage is calcium gluconate. Narcan is an opioid agonist and might be needed if the mother took morphine during the labor and delivery. 

Magnesium sulfate potentiates morphine at the spinal level. Anesth Ana/ 2000 90 913-917. 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

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