Magic angle spinning , solid-state development

Abstract Membrane proteins represent an important and challenging frontier in structural biology they mediate fundamental and medically important processes but are challenging targets for structure/ function studies. Magic angle spinning solid-state NMR methods for structure determination of proteins have developed rapidly in... 

The now wide-spread use of solid state NMR techniques such as magic angle spinning (MAS) led to a need for calculations of NMR parameters such as chemical shifts and quadrupole coupling constants. A notable achievement this century has been the development of a method to calculate NMR chemical shielding in periodic solids. This will be described in the following section along with developments in the calculation of other properties. 

Currently, solid-state NMR spectroscopy is a rapidly developing technique in all branches of chemistry. Solid-state NMR spectra are capable of providing information that is difficult or impossible to obtain from measurements in solution. In isotropic solutions, or in the fast Magic Angle Spinning (MAS) spectra of solids, the observed isotropic chemical shift represents the result of motional averaging of the principal components (5n, 22, and 33) of the chemical-shift tensors. The spinning rate decreases. 

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