Madecassic acid

A novel dimethyl ester -lactone from Dammar resin has been shown to have the structure (210) by AT-ray analysis. A very probable biogenesis from asiatic acid [(211)— (212) (210)] has been suggested. Madasiatic acid (213), a close relative of asiatic and madecassic acids, has been isolated from Centella asiatica Protection of the vicinal diol system, followed by oxidation to the 6-ketone and Wolff-Kishner reduction yielded 2o,3)5-dihydroxyurs-12-en-28-oic acid. Rubitic... 

Four triterpenes (asiatic acid, madecassic acid, asiaticoside, madecassoside) were extracted from Centella asiatica and baseline resolved on a Cj colunm... 

A modified TLC method from the European Pharmacopoeia was used for identification of four triterpenoids from Centella asiatica [30]. The plant extract was applied onto a silica gel 60 F254 TLC plate, which was developed using ethyl acetate-methanol (60 40, v/v). The bands were visualized by anisaldehyde derivatization reagent. The identity of four determined triterpenoids—madecassoside, asiaticoside, madecassic acid, and asiatic acid— was confirmed by offline TLC-MALDI-MS analysis. The adsorbent containing the analytes was scraped from the TLC support and the triterpenoids were reextracted using methanol and subjected to MALDI plates, along with the matrix, for MS analysis. 

Triterpenoid centellosides of Centella asiatica (CA) have been used as an ingredient in a wide range of applications that include healthcare. The triterpenoid centellosides specific constituents, namely, asiatic acid, asiaticoside, madecassic acid, and madecassoside, have been extensively researched and reported to have many health and therapeutic benefits. 

Bonte F, Dumas M, Chaudagne C, Meybeck A (1994) Influence of asiatic acid, madecassic acid and asiaticoside on human collagen I synthesis. Planta Med 60 133-135... 

N.A. Triterpenoid, saponins, oleic acid, vellarin, hydrocotyline, sitosterol, asiatic, madecassic, madasiatic acids, asiaticoside.99 100-115 116311 Treat skin disease, leprosy, antipyretic, detoxicant, diuretic, antirheumatic, mild diuretic, sedative, and peripheral vasodilator. 

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