Macrophage targeted

OSTROFF ET AL. 0-Glucan-Based Macrophage-Targeted Adjuvant... 

OSTROFF ET AL. P-Glucan-Based Macrophage- Targeted Adjuvant SI... 

Barton, N. W., Brady, R. O., Dambrosia, J. M. et al. Replacement therapy for inherited enzyme deficiency-macrophage-targeted glucocerebrosidase for Gaucher s disease. N. Engl. J. Med. 324 1464-1470,1991. 

In this chapter, we will review studies on formulation variables affecting monocyte and macrophage targeting (e.g., size and number of vesicles), in vitro characterization in cell cultures, and in vivo immunomodulation and anti-inflammatory responses. 

Tabled Visceral Reponaea to Macrophage-Targeted Glucoceiebiosidnae Time Course and Effects ot Doaa Reduction...

Figure 12 Photograph of an 8-year-old girl ridi Gaudier disease before (PRE) and after (POST) 26 months of treatment with macrophage-targeted glncDcerehmsidaae at a dose of 60 UAe every 2 weeks. Marked reduction in visceromegaly is evident.

Table 4 Quaotitmive Skeletal Responses to Macrophage-Targeted Glucocerebroaidase...

Medicine in New York using glucocerebrosidase that had been produced lecont-binantly in Chinese hamster ovary cells. The enzyme obtained from these cells was modified by exposure to the- same these cxogtycosidases used previously to produce mannose-terminal placental glucoceiebrosidase (Kg, 2). The clinical effectiveness of the recombinant macrophage-targeted enzyme was found to be... 

S. hi. Rich arris, T A. Olson, and J. m. McPherson Antibody response in patients with Gaucher disease after repealed infusion with macrophage-targeted glucocerehrosidase. 

Barton NW, Brady RO, Dambrosia JM, et al. Replacement therapy for inherited enzyme deficiency—macrophage-targeted glucocere-... 

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