Macrocyclic trichothecene mycotoxins roridin

Islam, Z., Amuzie, C.J., Harkema, J.R., Pestka, J.J. (2007). Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin A kinetics and potentiation by bacterial lipopolysaccharide coexposure. Toxicol. Sci. 98 526-41. 

Mycotoxins may include butanol, estrogenic compounds (e.g., zearalenone), heptanone, lactones, lactams (patulin), stachybotrylactones, stachybotry-lactams, 2-pentylfuran, 2-hexanone, 2-methyl-1-propanol, 3-methylfuran, 2-methylisoborneol, 3-methyl-2-butanol, and macrocyclic trichothecenes (Satratoxins F, G. and H, Roridine, Verrucarinj, and Trichoverrols). 

R Macrocyclic ester or ester-ether bridge between carbons 4 and 15. The most abundant macrocyclic trichothecenes are verrucarins, roridins, and satratoxin H. Source for this statement Jarvis BB. Macrocyclic trichothecenes. In Sharma RP, Salunkhe DK, eds. Mycotoxins and Phytoalexins. Boca Raton, Fla CRC Press 1991 361-421. 

A potentially important application area for capillary SFC and SFC-MS is in the analysis of thermally labile molecules not readily amenable to gas chromatography, such as mycotoxins of the trichothecene group (48,49). Figure 14 shows a fast separation of four trichothecenes on a short 0.8 m x 25 pm column at 100 C with supercritical CO2 as the mobile phase. Diacetoxyscirpenol (DAS) and T-2 toxin are easily resolved while the two macrocyclic compounds, roridin A and verricarin J, are not well separated. However, even this level of separation is often sufficient given a highly selective detector such as the mass spectrometer. Application of SFC-MS to these compounds is described in detail elsewhere ( ). 

---