MIP-MS

Figure 15.9 Competitive morphine sensor response as a function of the morphine concentration (0-10 p-g/mL) present in the solution. Three sensor types were examined morphine molecular imprinted polymer (M-MIP), reference (O-MIP), and agarose-covered platinum electrode (Pt-Ag). Reprinted from Kriz and Mosbach (1995). Copyright 1995 Elsevier Science.

The different methods can be classified according to the use of the subproblems (NLPl), (NLP2), and (NLPF) and the specific specialization of the MILP (M-MIP) (see Fig. 10). Note that in cases (b) and (d), (NLPF) is used if infeasible subproblems are found. 

The OA method (Duran and Grossmann. 1986c Yuan et ai, 1988 Fletcher and Leyffer. 1994) arises when NLP subproblems (NLP2) and MILP master problems (M-MIP) with / = 7 are solved successively in a cycle of iterations to generate the points (.v. y ). The (NLP2) subproblems yield an upper bound that corresponds to the best current solution, UB = min (Z, ). The master problems (M-MIP) yield a non-decreasing sequence of lower bounds (Zl since linearizations are accumulated as seen in (M-MIP). The cycle of iterations is... 

The master problem (M-MIP) can be rather large in the OA method. One option is to keep only the last linearization point, but this may lead to nonconvergence even in convex problems (e.g., see Bremicker et al, 1990). A rigorous reduction of dimensionality without greatly sacrificing the strength of the lower bound can be achieved in the case of the largely linear MINLP problem... 

M-MIP, an electrode on which a molecular imprinting resin made by morphine Is fixed 0-MIP, an electrode on which a molecular imprinting resin made by L-phenylalanine anilide is fixed R-Ag, an electrode on which only agarose is fixed. 

Manczak M, Jiang S, Orzechowska B, Adamus G (2002) Crucial role of CCL3/MIP-1 alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. J Autoimmun 18 259-270... 

Laurence JS, Blanpain C, Burgner JW, Parmentier M, LiWang PJ (2000) CC chemokine MIP-1 beta can function as a monomer and depends on Phel3 for receptor binding. Biochemistry 39 3401-3409... 

Ottonello L, Montecucco F, Bertolotto M, et al. CCL3 (MIP-la) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell Signal 2005 17 355-363. 

Vicenzi E, Alfano M, Ghezzi S, et al. Divergent regulation of HIV-1 replication in PBMC of infected individuals by CC chemokines suppression by RANTES, MIP-lalpha, and MCP-3, and enhancement by MCP-1. J Leukoc Biol 2000 68(3) 405-412. 

Gorin, M. B., Yancey, S. B., Cline, J., Revel, J. P. and Horwitz, J. (1984). The major intrinsic protein (MIP) of the bovine lens fiber membrane characterization and structure based on cDNA cloning, Cell, 39, 49-59. 

Fig. 4. Chromatogram of (left) 100 pg of a mixture of (Z)-L-Ala-L-Ala-OMe and (Z)-D-Ala-D-Ala-OMe on a (Z)-L-Ala-L-Ala-OMe-imprinted MIP-phase, gradient elution (right) 1 mg of a mixture of (Z)-L-Ala-L-Ala-OMe and (Z)-D-Ala-D-Ala-OMe on a (Z)-L-Ala-L-Ala-OMe-im-printed MIP-phase, isocratic elution. Reprinted with permission from Kempe M,Mosbach K (1995) Tetrahedr Lett 36 3563. Copyright 1995 Elsevier Science... 

Fig. 7. Separation of R- and S-propranolol using MIP particles as chiral additive in the background electrolyte, MIP prepared using S-propranolol as template. Reprinted with permission from Walshe M, Garcia E, Howarth J, Smyth MR, Kelly MT (1997) Anal Commun 34 119. Copyright 1997 The Royal Society of Chemistry...

Fig. 16. Screening of a steroid library using (top) MIP prepared against 11-a-hydroxyproges-terone (1), gradient elution using (bottom) non-imprinted control polymer, isocratic elution. Reprinted with permission from Ramstrom O, Ye L, Krook M, Mosbach K (1998) Anal Com-mun 35 9. Copyright 1998 The Royal Society of Chemistry...

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