Lysozyme biological macromolecules

The visuahzation of hundreds or thousands of connected atoms, which are found in biological macromolecules, is no longer reasonable with the molecular models described above because too much detail would be shown. First of aU the models become vague if there are more than a few himdied atoms. This problem can be solved with some simplified models, which serve primarily to represent the secondary structure of the protein or nucleic acid backbone [201]. (Compare the balls and sticks model (Figure 2-124a) and the backbone representation (Figure 2-124b) of lysozyme.)... 

Sashiva, H., Saimoto, H., Sgigemasa, Y. et al. (1990) Lysozyme susceptibihty of partially deacetylated chitin. International Journal of Biological Macromolecules, 12, 295-296. 

One of the key advances in computational chemistry during the last quarter of the twentieth century was the development of simulation methods to study motions of atoms and molecules in condensed-phase environments. The paper reviewed here is noteworthy for its pioneering application of molecular dynamics techniques to proteins, and (along with the 1976 Warshel and Levitt paper on lysozyme, discussed elsewhere in this issue) can be considered to herald an increased interest among the computational chemistry community on the problems dealing with the structures and dynamics of biological macromolecules. 

Aiba, S. 1992. Studies on chitosan 4. Lysozymic hydrolysis of partially A-acetylated chitosans. International Journal of Biological Macromolecules 14 225-228. 

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